Abstract:【Objective】 To investigate and analyze the serum adhesion and stress related indexes of patients with total laparoscopic hysterectomy during the perioperative period. 【Methods】 90 patients with total hysterectomy in our hospital from April 2012 to January 2014 were selected in our study, and 90 cases were randomly divided into control group (open operation group) 45 cases and observation group (laparoscopic operation group) 45 cases according to the operation types, then the serum adhesion and stress related indexes of two groups were analyzed and compared at day 2 before the operation and at days 3,5,7 after the operation . 【Results】 The serum adhesion and stress related indexes of observation group at days 3,5,7 after the operation were all obviously lower than those in control group, and the stress related indexes of observation group at third day after the operation were all obviously higher than those at other times, and the adhesion related indexes at fifth day after the operation were higher than those at other times, all P <0.05, there were all significant differences. 【Conclusion】 The change of serum adhesion and stress related indexes of patients with total laparoscopic hysterectomy during the perioperative period are obvious, while the fluctuation is all smaller than those of patients with open operation, so it is more helpful for the postoperative rehabilitation of patients.