The correlation between the level of the expression of Ck20mRNA in the peritoneal cavity washes and the different surgical methods of the colorectal cancer
【Objective】 To investigate the clinical significance of the CK20mRNA in the peritoneal cavity washes, and the clinical value of the laparoscopic resection of colorectal cancer. 【Methods】 49 patients with colorectal cancer and conscience tumor were selected from our hospital . In order to explore the clinical value of the CK20mRNA and evaluate the practicality of laparoscopic resection of colorectal cancer, RT-PCR was used to detect the expression of CK20mRNA in the peritoneal cavity washes. 【Results】 The expressions of CK20mRNA were negative in the peritoneal cavity washes samples of 10 patients with non-malignant disease by operations on abdomen. Meanwhile, the total positive rate of expression of CK20mRNA were 40.2% (47/117) in the patients with colorectal carcinoma, and the expression of the CK20mRNA on pre-, during and post-operation didn't have significant difference (P >0.05). The positive expression rates of CK20mRNA in patients of the two groups (Laparoscopy group and Laparotomy group) pre-, during and post-operation didn't have significant difference (P >0.05). 【Conclusion】 Laparoscopic resection of colorectal cancer is safe and effective in the treatment of colorectal cancer. There are no significant differences in the efficacy of radical operation for patients with colorectal carcinoma by laparoscope and open radical surgery.
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韩云,杨生虎,李晓峰,杨立平,耿兴隆HAN Yun, YANG Sheng-hu, Li Xiao-feng, YANG Li-ping, GENG Xing-long.腹腔灌洗液中CK20mRNA水平与 结直肠癌不同术式的研究[J].中国内镜杂志,2015,21(1):13-16