Abstract:【Objective】 To study and investigate the comprehensive application effect of hysteroscopic operation combined with gestrinone in the treatment of adenomyosis. 【Methods】 86 patients with adenomyosis in our hospital from January 2011 to February 2013 were enrolled , and they were randomly divided into control group (gestrinone group) 43 cases and study group (hysteroscopic operation combined with gestrinone group) 43 cases, then the uterine volume, algomenorrhea degree and uterine artery hemodynamics indexes, serum disease related indexes of two groups before and after the treatment were compared. 【Results】 The uterine volume of study group at 1st,3rd and 6th month after the treatment were smaller than those of control group, the algomenorrhea degree was lighter than those of control group, uterine artery hemodynamics indexes were lighter than those of control group, serum disease related indexes were lower than those of control group, all P <0.05, the items of two groups after the treatment had significant differences. 【Conclusion】 The comprehensive application effect of hysteroscopic operation combined with gestrinone in the treatment of adenomyosis is better, and it has better improvement role for the disease evaluation indexes of patients.