Abstract:【Objective】 To observe the value of endomicroscopy lumbar discectomy and fenestration discectomy applied in patients with lumbar disc herniation. 【Methods】 122 cases of patients diagnosed as lumbar disc herniation treated in our hospital from December 2008 to 2013 were selected and divided into endoscopic group and fenestration group by different treatments. Endomicroscopy lumbar discectomy was given in endoscopic group, while fenestration discectomy given in fenestration group. Anti-inflammatory and anti-infective therapy were given in both of the two groups. All the patients were followed up more than 3 months and the effect of treatment was compared. 【Results】 53 cases in endoscopic group were excellent, 3 were good, and the excellent and good rate of treatment was 91.80%. 44 cases in fenestration group were excellent, 5 were good, and the excellent and good rate of treatment was 80.33%. The effect in endoscopic group was better than that in fenestration group (χ2=9.304, P<0.05). The average blood loss in endoscopic group was less than that in fenestration group (t=34.781, P<0.05), and the average surgery time, bed time and total length of hospital stay in endoscopic group were less than those in fenestration group(t=16.934, 41.719, 6.076, all P<0.05). There were no differences of postoperative complications such as cerebrospinal fluid leakage, nerve root injury and postoperative lumbago (χ2=0.052, 0.000, 0.105, all P>0.05). There was no statistical difference of nucleus weight in the two groups (t=0.382, P<0.05). 【Conclusion】 The endomicroscopy lumbar discectomy was better and safer than fenestration discectomy. It was worth using in the clinical practice.