【Objective】 To analyze the effectiveness of minimally invasive surgical management for lumbar spondylolisthesis via endoscopic X-Tube system assisted Sextant-R system. 【Methods】 52 patients with lumbar spondylolisthesis included isthmic spondylolisthesis (n=22) and degenerative spondylolisthesis (n=30), were performed minimally invasive via X-Tube system for decompression and fusion, via Sextant-R system for fixation and reduction. VAS score system was used to evaluate back pain the pre-and post operative (12 months). JOA score system was used to evaluate the pre-and post operative (12 months) score and improvement rate. X-ray was used to evaluate the reduction of spondylolisthesis and the fusion rate post operative (12 months). 【Results】 The VAS and JOA score showed statistical significance (P <0.05) between preoperative and 12 months postoperation. The reduction of spondylolisthesis was 91.7%, and the fusion rate was 94.1% at 12 months postopertively. There were no cage displacement and subside, no screw fracture in all patients. 【Conclusion】 Minimally invasive surgical management for lumbar spondylolisthesis via X-Tube system assisted Sextant-R system is less injure and short recovery time with safety and effectiveness.