丙泊酚复合地佐辛与或右美托咪定在老年患者ERCP术麻醉中疗效对比

Anesthetic effects of propofol combination dezocine or dexmedetoidine in elderly patients received ERCP

摘要:

目的 探讨并比较丙泊酚复合地佐辛及复合右美托咪定在老年患者ERCP术麻醉中的疗效。方法 将42例接受择期ERCP术的老年患者按照随机数表法分为A组及B组，A组接受丙泊酚复合右美托咪定麻醉，B组则接受丙泊酚复合地佐辛麻醉。观察并比较两组患者在诱导前、诱导后、进镜时、术中以及麻醉苏醒时平均动脉压（MAP）、心率（HR）、氧饱和度（SPO2）以及呼吸频率（RR）；采用放射免疫法（RIA）分别在术前、术中及术后对两组患者血清中皮质醇浓度进行检测。结果 与诱导前相比，A组患者在诱导后MAP及RR显著降低（P <0.05）；B组患者在诱导后MAP及RR显著高于A组（P <0.05）；与术前相比，两组患者术中及术后血清皮质醇浓度均显著升高（P <0.05）；B组患者术中及术后血清皮质醇浓度显著低于A组（P <0.05）。结论 丙泊酚复合地佐辛适用于老年患者ERCP术的麻醉。

Abstract:

【Objective】 To explore and compare the anesthetic effects of propofol combination dezocine or dexmedetomidine in elderly patients received ERCP. 【Methods】 42 elderly patients received ERCP were divided into group A and group B evenly and randomly. Group A received combination anesthesia of propofol and dexmedetomidine, while group B received combination anesthesia of propofol and dezocine. MAP, HR, SPO2 and RR were observed and compared before induction, after induction, during endoscopic entry, during ERCP procedure and after ERCP. RIA was utilized to determine serum level of cortisol before, during and after ERCP. 【Results】 MAP and RR decreased significantly in group A after anesthesia introduction (P <0.05); MAP and RR was significantly higher in group B than group A after anesthesia introduction (P <0.05); serum level of cortisol increased significantly in all patients during and after ERCP than before ERCP(P <0.05); serum level of cortisol was significantly lower in group B than group A during and after ERCP (P <0.05). 【Conclusion】 Combination anesthesia of propofol and dezocine is proper for anesthesia in elderly patients received ERCP.