Abstract:【Objective】 To investigate the feasibility and clinical value of ultrasound-guided gallbladder catheter drainage combined with choledochoscope in aged and high-risk patients with acute calculous cholecystitis. 【Methods】 Clinical data of 41 patients admitted from July 2011 to June 2013 were retrospectively analyzed. Patients were performed the ultrasound-guided gallbladder catheter drainage, the expansion of the sinus tracts and the removing of gallbladder stones with choledochoscope. 【Results】 A total of 37 cases (90.2%) were cured successfully in all of 41 cases. Two cases (4.9%) were diverted into laparoscopic cholecystectomy and 2 cases (4.9%) were discharged in remission after extubation. The main complications were bleeding (4.9%), intestinal fistula (4.9%) and biliary fistula (2.4%). In all follow-up patients, one was stone recurrence, and another was indigestion. 【Conclusion】 This approach was safe, effective and has significant feasibility, great clinical value in aged and high-risk patients with acute calculous cholecystitis.