Abstract:【Objective】 To evaluate the safety and technical feasibility of uniportal complete video-assisted thoracoscopic (cVATS) lobectomy. 【Methods】 From June 2012 to November 2013, 106 patients underwent uniportal cVATS procedure including, among which 62 wedge resection, 19 pleural or mediastinal tumor resection, 11 mediastinal lymph node biopsy, 14 lobectomy with 9 lung cancer and 1 segmentectomy. The perioperative data were collected and reviewed. 【Results】 No postoperative severe complications and death occurred. 14.3% (2/14) converted to biportal cVATS or open surgery. Mean surgical time was recorded as 191 (90~420)min and mean blood loss 381 (5~3 500) mL. Mean number of lymph nodes was 16.4 (6~31) and mean number of explored stations was 5.2 (4~6). Overall, the median duration of chest-tube placement was 2.3 (1~6) days, and median length of stay was 5 (3~10) days. 【Conclusion】 Uniportal cVATS is a safe and feasible surgical procedure with less postoperative pain especially when performed by surgeons experienced with biportal technique.