Abstract:【Objective】 To investigate the method of reducing adverse effects of controlled hypotension on the optic nerve decompression surgery. 【Methods】 40 cases with optic nerve decompression surgery were randomly divided into group A (continued controlled hypotension), group B (stepping controlled hypotension), n =20. The lactate content difference in Arterial-venous (Da-jvL) at the start of surgery (T0) were detected and calculated,1min before cut sphenoid (T1), after opticed nerve sheath incision 1 min (T2),after going into the recovery room 10 min (T3);The scores of endoscopic surgical field quality (SESFQ) were recorded at T1,T2,T3. Operation time (OT) and number of cases with muscle aches or headaches within postoperative 24 hours were recorded. 【Results】 Da-jvL of two group at T1,T2,T3 were higher than which of T0 (P <0.05). Da-jvL of group A at T1,T2,T3 were higher than which of group B (P <0.05). and Da-jvL of group B at T2were higher than which at T1,T3 (P <0.01); SESFQ of group B at T1,T2 were higher than group A (P <0.05). and SESFQ of group B at T3 was lower than which at T1,T2 (P <0.05); Number of cases with postoperative adverse reactions of group A were higher than that of group B (P <0.05). 【Conclusion】 Stepping controlled hypotension can effectively improve poor metabolism of tissues and cells within perioperative,and reduce the incidence of adverse events, and increase patients safety with optic nerve decompression surgery.