Abstract:【Objective】 To observe the clinical curative effect of laparoscopic operation in the treatment of 46 pancreatic pseudocyst and compared with the open surgery. 【Methods】 46 cases pancreatic pseudocyst were selected and divided into two groups (observation group and control group). Each group was 23 cases. The patients in observation group were given laparoscopic operation and the patients in control group were got open surgery. 【Results】 The cure rate and recurrence rate of the treatment group was 82.6% and 13.0%,the control group was 69.7% and 17.4%, there was no significant difference between the two groups (χ2=1.08, 0.00, P >0.05). But the bleeding volume (72.9±15.9) mL, operation time (120.3±33.5) min and length of hospital stay (120.3±33.5) min of observation group was all much shorter than the control group (151.8±34.1)mL, (154.8±42.7)min, (14.7±4.1) respectively)(t=10.06, 3.05, 5.98, P <0.01). 【Conclusion】 In the strict control of surgical indications at suitable operation time, apply Laparoscopic Operation for the Treatment of Pancreatic Pseudocyst by professional skilled physicians can obtain satisfactory curative effect, with shorter operation time, less time in hospital, less time to recovery, reduce the economic burden of patients and their families. Therefore it is worth popularizing widely.