Abstract:【Objective】 To study the therapeutic effect of intracordal injection of diprospan on chronic hypertrophic laryngitis under self-retaining laryngoscope and endoscope. 【Methods】 40 cases of chronic hypertrophic laryngitis were treated by intracordal injection of diprospan under general anesthesias with self-retaing laryngoscope and endoscope. The pre-and post-operative voice were estimated with acoustic analysis, voice handicap index(VHI), and fribrolaryngoscope. 【Results】 Jitter, shimmer, NHR and VHI decreased after surgery and the difference was significant(P <0.05). The congestion or edema of vocal cord after surgery disappeared: 28 patients (28/40); obviously lessened: 10 patients(10/40); unobviously lessened: 2 patients(2/40). Vocal cord atrophy wasn't found after surgery. 【Conclusion】 Vocal cord injection of diprospan under self-retaining laryngoscope and endoscope to treat chronic hypertrophic laryngitis is an effective treatment with seldom complication, clear vision, meticulous and exact operating.