丹参多酚酸盐对胸腔镜术中单肺通气 相关肺损伤的保护作用*

Protective effects of salvianolate against lung injury in patients received OLV during thoracoscopic surgeries

摘要:

目的 观察丹参多酚酸盐对胸腔镜术中单肺通气相关肺损伤的保护并探讨其相关机制。 方法 将44例接受胸腔镜手术治疗的单肺通气（OLV）患者平均随机分为对照组与治疗组，治疗组在OLV前进行丹参多酚酸盐静脉滴注预处理。分别在OLV开始时、OLV开始后1 h及OLV开始后2 h观察并比较两组患者血清中白介素-6（IL-6）、超氧化物歧化酶（SOD）、丙二醛（MDA）、全血中性粒细胞比例（PMN%）以及OLV前后肺组织中表面活性蛋白A（SPA）的水平。 结果 与OLV开始时相比，所有患者在OLV后血清中IL-6及MDA水平显著升高，血清中SOD水平及肺组织中SPA水平显著降低，差异均有显著性（P <0.05）；在OLV后，与对照组相比，治疗组血清IL-6及MDA显著降低，血清SOD及肺组织SPA水平则显著升高（P <0.05）。 结论 丹参多酚酸盐预处理可对胸腔镜手术中OLV相关肺损伤起保护作用。

Abstract:

【Objective】 To observe the effects of salvianolate on lung injury during OLV in thoracoscopic surgeries and to explore the related mechanisms. 【Methods】 44 patients received OLV during thoracoscopic surgeries were divided into control group and treatment group evenly and randomly. Treatment group received additional pretreatment of salvianolate before OLV. Serum levels of IL6, SOD and MDA, whole blood PMN%, and protein level of SPA in lung tissue before OLV, 1 hour after OLV and 2 hours after OLV were observed and compared. 【Results】 Serum levels of IL-6 and MDA increased while serum SOD and SPA in lung tissue decreased significantly after OLV (P <0.05); compared with control group, serum levels of IL-6 and MDA decreased, while serum level of SOD and lung tissue SPA increased significantly in treatment group after OLV. 【Conclusion】 Pretreatment of salvianolate protects lung after OLV during thoracoscopic surgeries.