Abstract:【Objective】 To analyze the curative effect, safety and prognosis of gastric stromal tumor treated by endoscopic ultrasonography-guided dual duct endoscopy nylon ring band ligation. 【Methods】 31 patients with gastric stromal tumor were treated by endoscopic ultrasonography-guided dual duct endoscopy nylon ring band ligation. The follow-up was performed on day 1, at 3month and 1 year after band ligation and every year thereafter. 【Results】 29 cases were resected successfully and 2 cases were failure. No perforation and hemorrhage occurred in the 29 cases. After followed-up for 3 to 24 months, none of the patients had local recurrence. 【Conclusion】 Endoscopic ultrasonography-guided nylon ring band ligation was an effective and safety endoscopic technique for the treatment of gastric stromal tumor, but strict screening should be carried out according to lesion features and further studies involving more samples and enough follow-up are necessary to evaluate the long-term results.