Abstract:【Objective】 To explore the value of endoscopic guide wire technique in the clinical treatment of acute cholangitis. 【Methods】 A retrospective analysis of the past 30 months in our hospital with acute cholangitis was conducted, and according to the different treatment methods, endoscopic treatment group and surgical operation treatment group were compared . 【Results】 The total hospital charges, average hospitalization days, operation complications, mortality in endoscopic treatment group were lower than the surgical operation treatment group (P <0.05), the result was satisfactory. 【Conclusion】 The endoscopic guide wire technique has a good application value in the clinical treatment of acute cholangitis, which is worthy of promotion.