Abstract:【Objectives】 To discuss the risk factors of gallbladder polyps recrudesce after cholecystolithotomy with gallbladder reservation. 【Methods】 The patients after minimally-invasive operation with gallbladder reservation because of polyps of gallbladder were followed up for at least one year. In this population, the patients with recurrence after surgery were as the case group, those patients with no recurrence after surgery were as the control group. Through collection of general data of selected cases, relevant information of ultrasound examinations of gallbladder and history data of the patients questionnaires were completed. Relevant factors of gallstone recurrence of patients were observed through statistic analysis. Main factors go as follows: gender, age, nation, career, BMI, gallbladder polyps family history, smoking and drinking history, diet, body mass index, and the pathology of polyp. 【Results】 By single factor regression analysis, the risk factors of gallbladder polyps recurrence included age, family history of gallstone disease, smoking and greasy diets. Multivariate analysis showed that, gallbladder polyps family history, smoking and cholesterol polyps were the risk factors of gallbladder polyps recurrence. 【Conclusion】 The main hazards of gallbladder polyps recurrence were age, family history of gallstone disease, smoking and greasy diets.