Abstract:【Objective】 To summarize the clinical experience of thoracoscopic R3 sympathectomy with a single mini incision in the single lumen endotracheal intubation for palmar hyperhidrosis. 【Methods】 From January 2012 to June 2013, 65 cases of primary hyperhidrosis patients were treated by thoracoscopic R3 sympathectomy with a single mini incision in the single lumen endotracheal intubation. A single lumen endotracheal intubation (non artificial pneumothorax).The patient was 75° semireclining position. The subaxillary small incision at the outer edge of mammary glands at 3rd intercostal were selected on female patients. The periareolar incision was selected on lanky man, while the incision at the outer edge of pectoralis at 3rd intercostal was selected on obesity man. 【Results】 65 cases of operations were successful without serious complications. The operation time (both sides) was 21 (15~35) min. The average postoperative hospital stay was 1.1(1~2) d. The mean follow-up was 6.2(1~14) months. Right pneumothorax (about 15%) in 2 cases, mild compensatory sweating (18.5%) in 12 cases, Postoperative follow-up showed no recurrence. Patients were satisfied. 【Conclusion】 Electric coagulation hook and 30°mirror from the same incision into the chest can obtain good vision and complete thoracic sympathectomy. This operation mode can be accurate positioning, safe and effective, less complications, concealing incision, in line with the requirements ofaesthetic. A single lumen endotracheal intubation anesthesia management was less cost and reduce the difficulty in operation,which can be worthy of clinical application.