Abstract:【Objective】 To investigate the clinical effect of micro-endoscopic discectomy (MED) in large lumbar discherniation treatment and analyze the advantage of this method. 【Methods】 Totally 126 large lumbar discherniation patients were investigated,including 65 patients treated with MED and 61 patients treated with conventional open surgery(OPEN). The clinical results: the blood loss in operation, the complication rate, the cost of treatment and the average hospital time were evaluated . 【Results】 Two groups of patients were followed up for 12 months or more. The operation blood loss, complication rate, postoperative effects were no significant difference between the two groups (P >0.05), but the group of MED had shorter average hospital time with the group of OPEN (9.5±2.3 VS. 14.3±3.6) (P <0.01), and less cost of treatment than that of the group of OPEN (P <0.05). 【Conclusion】 Compared with conventional open surgery group, MED is of smaller incision,less tissue trauma and quicker recovery,which can obtain the best clinical result and should be selected in large lumbar discherniation treatment.