Abstract:【Objective】 To compare the effects of difficult nasotracheal intubation with flexible ureteroscope and fiberoptic bronchoscope. 【Methods】 Sixty cases of patients with difficult tracheal intubation were randomly divided into two groups, nasotracheal intubation was respectively performed with flexible ureteroscope (n =30, group FU) and fiberoptic bronchoscopy (n =30, group FOB). MAP, HR and SPO2 were recorded at 4 time points: before induction of anesthesia (T1), just before intubation (T2), just after intubation (T3) and 5 minutes after intubation (T4); The success rate of intubation, intubation time (since the intubation operation to succeed) and the complications (cough, laryngeal spasm, agitation, respiratory depression, SPO2<90%, arrhythmia, etc.) were observed; Postoperative follow-up of patients were recorded with oropharyngeal and airway intubation injury. 【Results】 Compared to T2, the HR and the MAP were increased, and the SPO2 was decreased at T3 in both groups (P <0.05), but there were not significant differences between two groups (P >0.05); The one-time success rate of intubation in group FU and group FOB were respectively 90.0% and 93.3%, and the intubation time were respectively (180±90) s and (156±66) s in group FU and group FOB, the differences were not statistically significant between two groups (P >0.05). SPO2 in the intubation process in both groups was maintained at 91~100%, there were no complications such as fierce cough, laryngeal spasm, agitation and respiratory depression. There was 1 case of minor sore throat in patients postoperative follow-up in each group, and no hoarseness and injury related catheter in both groups. 【Conclusion】 Compared with the fiberoptic bronchoscopy, difficult nasotracheal intubation guided by flexible ureteroscopy also is feasible and effective, this method could be widely used in basic hospital.