Abstract:【Objective】 To evaluate the clinical value and efficacy of EUS, TUS and MRCP in the diagnosis of CBDS. 【Methods】 All clinical data of patients with suspected CBDS which were diagnosed with EUS, TUS and MRCP were collected in our hospital from July 2012 to January 2013, and the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of all above ways were evaluated and compared. 【Results】 Compared with TUS, MRCP and EUS had obvious advantages in the sensitivity, specificity, positive and negative predictive value and accuracy (P <0.05), and especially in sensitivity, negative predictive value and accuracy (P <0.01). EUS had obvious advantages in the sensitivity and accuracy compared with MRCP (P <0.05). 【Conclusion】 In the diagnosis of CBDS, EUS and MRCP are better than TUS; EUS has better advantages compared with MRCP, especially for the lower biliary microlithiasis.