Abstract:【Objective】 To evaluate the efficacy and safety of laryngeal mask airway ventilation under general anesthesia fibrobronehoscope with argon plasma coagulation in treating central airway diseases. 【Methods】 21 patients with central airway diseases were treated by fibrobronchoscope with argon plasma coagulation laryngeal under mask airway ventilation and general anesthesia. SP, DP, HR and SPO2 were continuously monitored during anesthesia and measured at 5 min after entering the surgery room (T1), during fibrobronchoscope (T2) and at the immediately after the bronchoscope extubating the glottis (T3). The peak values of airway pressure after inserting laryngeal mask/tracheal catheter (P1), immediately after inserting fiberoptic bronchoscope (P2) and immediately after extraction of fiberoptic bronchoscope (P3) were recorded. The operation time, ventilation time, breathing recovery time, wake time and extubation time were measured. The complications were observed in all patients during and after operation. 【Results】 21 patients received 32 argon plasma coagulation procedures. The operation time was 15~50 min and the ventilation time was 25~60 min. SP, DP, HR and SPO2 were steady during the operation. The peak values of airway pressure were not statistically significant (P >0.05). No complications were observed in all cases during and after operation. 【Conclusion】 The laryngeal mask airway ventilation under general anesthesia fibrobronehoscope with argon plasma coagulation in treating central airway diseases is efficacious and safe. This method is easy to keep stablehemodynamics and reduces the fluctuation range of the peak inspiratory airway pressure with steady and rapid recovery and less complications of airway.