Abstract:【Objective】 To explore the effect of advanced colorectal cancer with neoadjuvant chemotherapy followed by laparoscopic operation treatment. 【Methods】 From 2008 July to 2012 December, among the patients, 4 cycles in 78 patients with advanced colorectal cancer underwent preoperative chemotherapy (FOL FOX4), chemotherapy after 3 weeks of laparoscopic assisted colorectal cancer radical resection. 【Results】 After neoadjuvant chemotherapy, tumor TNM stage was reduced, no adverse reaction occurred above level three. Radical resection in 78 cases, the 4 cycle of chemotherapy were performed laparoscopic colorectal cancer operation successfully, without conversion to laparotomy, the average operation time was 160 min(120~220 min), the average intraoperative bleeding was 150 mL (100~400 mL), postoperative gastrointestinal function recovery time of 1~2 d, the average length of time (8~14 d), no serious intraoperative and postoperative complications, postoperative pathological examination in laparoscopic operation: 786 lymph nodes were dissected, transfer 201. There were 9 patients with postoperative liver and lung metastasis in postoperative death within 2 years, 3 cases of abdominal postoperative metastasis, 2 patients died of brain metastasis, loss to follow-up of 7 cases, 57 cases were survived so far found local recurrence, distant metastasis. 【Conclusion】 Advanced colorectal cancer underwent neoadjuvant chemotherapy can significantly reduce tumor clinical stage, increase the R0 removal rate, reduce tumor volume at different degrees , reduce lymph node metastasis, combined with laparoscopic minimally invasive operation on colorectal cancer improves the chance of radical.
