Abstract:【Objective】 To study the clinical application significance of bronchoscopy for patients with severe brain injury combined with lung infections . 【Methods】 96 patients with severe brain injury combined with lung infections in our hospital were divided into observation group and control group randomly(48 patients in each group). The patients in control group were treated with conventional therapy. The patients in observation group were treated with bronchoscopy. The clinical treatment, arterial blood gas analysis, clinical indicators to improve the situation of the patients in two groups were compared and analyzed. 【Results】 Compared with control group, the patients in observation group the rates of significant efficiency and total effective were increased significantly(81.25% and 95.83%, P <0.05). The arterial blood gas analysis conditions in observation group, including SaO2, PaO2 and PaCO2 were improved significantly(P <0.05). Compared with control group, the time for infection control in observation group was shortened significantly (P <0.05). 【Conclusion】 The operation technology of bronchoscopy was simple, safe and effective, and it has a high clinical value.