腹腔镜卵巢打孔联合药物治疗难治性 多囊卵巢综合征临床分析

Clinical study on clomiphene-resistant polycystic ovarian syndrome with laparoscopic ovarian drilling combined with drugs

摘要:

目的 探讨腹腔镜卵巢打孔术（LOD）结合来曲唑（LE）对难治性多囊卵巢综合征（PCOS）不孕的治疗效果。方法 将72例患者随机分成研究组和对照组各36例，所有患者进行LOD。手术前后分别测血黄体生成激素（LH）、卵泡刺激素（FSH）、睾酮（T）及雌二醇（E2）水平，术后第9天起监测患者卵泡发育和排卵共3个周期，并记录妊娠数和流产数。结果 两组患者术后LH和T水平与术前相比均有显著性下降（P <0.05），两组E2水平术后均较术前降低，但研究组治疗后降低更为显著（P <0.05）。3个治疗周期内研究组排卵率明显高于对照组（P <0.05）。结论 LOD后结合氯米芬（CC）能明显改善难治性PCOS患者的排卵和受孕机会。

Abstract:

【Objective】 To evaluate the efficacy of laparoscopic ovarian drilling (LOD) combined with Letrozole (LE) in the treatment of clomiphene-resistant polycystic ovary syndrome (PCOS). 【Methods】 72 patients with PCOS were randomly divided into study group and control group with 36 cases in each group, and the serum concentrations of LH, FSH, T and E2 were respectively compared before and after operation. Ovarian follicular development, pregnancy rate and abortion rate were observed and compared between the two groups. 【Results】 There were significant decrease in level of LH and T after operations (P <0.05). The E2 level in study group after treatment was obviously lower than that in control group (P <0.05). The ovulation rate was significantly increased in study group compared with control group (P <0.05). 【Conclusion】 LOD combined with Letrozole could significantly increase the ovulation rate and pregnancy rate in patients with CC-resistant PCOS.