Abstract:【Objective】 To compare the cardiovascular responses to orotracheal intubation with Lightwand (LW) or Macintosh direct laryngoscope (MAC). 【Methods】 Forty gynecologial patients requiring orotracheal intubation were randomly allocated to LW (n=20) or MAC (n=20). Orotracheal intubation was performed using a LW or a MAC. Invasive systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded before and after induction, at the time of seeing light spot or exposing the glottic opening, at intubation and 5 minutes after intubation with 1-minute interval. The intubation time was noted. The time to maximal blood pressure (BP) and HR was also noted. 【Results】 The intubation time was longer in MAC group than in LW group (P <0.05). After anesthetic induction, SBP, DBP and MAP in both groups decreased significantly compared to the preinduction values(P <0.05). At the time of seeing light spot or exposing the glottic opening, BP and HR in two groups were not significantly different compared to the postinduction values (P >0.05). After intubation, BP in both groups increased greatly in comparison with postinduction (P <0.05), but these hemodynamic changes lasted only 1 to 2 minutes and then decreased gradually to the postinduction level. The rise of BP in both groups did not exceed the preinduction values (P >0.05). After intubation, HR in two groups increased significantly compared to the preinduction and postinduction (P <0.05), and increase in HR lasted for 3 minutes. There was no significant difference in BP and HR at any time point between two groups (P >0.05). 【Conclusion】 The cardiovascular responses to orotracheal intubation using a LW or MAC were similar.