腔镜与开放喉返神经探查术对机体 免疫功能影响的对比研究

Comparative study on effects of endoscopic and open recurrent laryngeal nerve exploration surgery on immune function

摘要:

目的 探讨腔镜与开放喉返神经探查术对机体免疫功能的影响。方法 32例甲状腺肿瘤患者前瞻性分为腔 镜组和开放组，各组均为16例。于术前及术后24 h采取外周静脉血，分别测定CD3、CD4+、CD4+/CD8+、IgA、IgG、IgM、红细胞C3b受体花环率和红细胞免疫复合物花环率。结果 32例均获手术成功。腔镜组和开放组CD3细胞和CD4+细胞的百分比在术后24 h较术前均有下降，且差异有显著性（P <0.05）；但两组间差异无显著性（P >0.05）。其余各免疫指标手术前后的变化腔镜组与开放组相比差异均无显著性（P >0.05）。结论 腔镜与开放喉返神经探查术对机体免疫功能的抑制程度相似。但是腔镜喉返神经探查术有更佳的美容效果，也是安全的手术方式。

Abstract:

【Objective】 To compare the effects of endoscopic and open the recurrent laryngeal nerve exploration surgery on the immune function. 【Methods】 32 cases of thyroid tumor patients were prospectively divided into two groups, the endoscopic group and traditional group, each 16 cases . CD3, CD4+, CD4+/CD8+, IgA, IgG, IgM, C3b receptor rosette rate of red blood cells and red cell immune complex rosette rate were measured from preoperative and postoperative 24 h taken peripheral venous blood. 【Results】 For the endoscopic group and open group, CD3 cells and CD4+ cell percentage were decreased 24 h after surgery than before surgery, and the difference was statistically significant (P <0.05); but no significant difference between the two groups (P >0.05). Compared to the rest of the immune indexes changes before and after the endoscopic surgery group.The difference was not statistically significant for open group (P >0.05). 【Conclusion】 Endoscopic and open the recurrent laryngeal nerve exploration surgery have no difference in the degree of inhibition of the immune function. Endoscopic recurrent laryngeal nerve exploration surgery is a feasible and safe, excellent cosmetic surgery.