【Objective】 To investigate the clinical manifestation and emergency endoscopic diagnosis and therapy in acute gastrointestinal bleeding post-ERCP. 【Methods】 A retrospective study was performed in our institution of 753 patients who underwent ERCP between September 2007 to September 2012.There were 8 cases with acute gastrointestinal bleeding. The manifestation was melena or and haematemesis in 1-3 days after ERCP. 7 cases underwent emergency endoscopy and 5 cases implemented therapeutic endoscopy.1 case accepted drugs only. 【Results】 Bleeding was stopped in all cases successfully. 【Conclusions】 Emergency endoscopic diagnosis and therapy is feasible, effective, and safe in patients with acute gastrointestinal bleeding post-ERCP.