Abstract:【Objective】 To investigate the clinical effects of ureteroscopic holmium laser lithotripsy with combined 4F ureteral catheter irrigation in treating upper urinary tract stones. 【Methods】 Clinical data of 86 cases with upper urinary tract stone in our hospital from June 2011 to June 2012 underwent ureteroscopic Ho: YAG laser lithotripsy were analyzed retrospectively. 86 patients were divided into two groups randomly.43 patients received ureteroscopic holmium laser lithotripsy combined with paracalculous 4 F ureteral catheter above the stones irrigation in treating upper urinary tract stone (group A), the other without paracalculous 4 F ureteral catheter irrigation (group B). Comparison of two groups of patients were stone-free rates, operation time, operation complication rate, hospital stay and cost of hospitalization. 【Results】 Stone-free rates, operation time, operation complication rate, hospital stayand cost of hospitalization for group A and B patients were 93. 0% ( 40/43)/ 83. 7% ( 36/43), (30 ±5) min /(42±5)min, (3.4± 0.4)d/(3.3±0.5)d, 11. 6% (5/43)/13.9% (6/43) and (8526 ±180)/(8639±150) , respectively. The differences between stone-free rates and operation time were statistically significant(P <0.05). However, operation complication rate, hospital stay and cost of hospitalization had no significant difference between group A and B (P >0.05). 【Conclusion】 Ureteroscopic Ho:YAG laser lithotripsy with ureteral catheter irrigation leads to better visibility of the surgical field, prevents the calculus from moving upward, and delivers substantial effects and safety. The operation is simple and convenient, can effectively improve the stone-free rate, shorten the operation time, does not increase the operation complications with good clinical application value.