【Objective】 To investigate the combination therapy for large colorectal polyps in children by endoscopic high-frequency electro resection, nylon loop/titanium clip and to evaluate its safety. 【Methods】 55 children with large colorectal polyps (diameter of the base>2.0 cm) were treated with endoscopic high-frequency electro resection. 【Results】 55 cases with 68 colorectal polyps were all resected successfully by endoscopic high-frequency electro resection without perforation or postpolypectomy coagulation syndrome. 2 cases showed delayed minor bleeding and bleeding was stopped by conservation treatment. 【Conclusion】 Endoscopic high-frequency electro resection and nylon loop/titanium clip is a safe and reliable method to resect large colorectal polyps in children.