Abstract:【Objective】 To investigate the effect of multiple endoscopic on bilateral upper urinary tract stones .【Methods】 Forty-two patients, male 24,female 18, aged 25-72, were treated .They were 7patients with left kidney and right ureteral stone,5 left kidney and two sides ureteral stone ,6 right kidney and two sides ureteral stone,7 right kidney and flee ureteral stone ,12 two sides ureteral stone ,and 5 two sides kidney stone.Ureteral stones and simple kidney stones surgery underwent ureteroscopic and flexible ureteroscope. Complex kidney stones surgery was carried out under nephrolithotomy and bladder soft lenses. After gravel,leaved double J tube in the ureter,treated 3~5d anti-infection,and removed double J tube after 1or 2 month.【Results】 Forty-one were technically successful in the forty-two patients. The mean operative time was 50-180min and the blood loss in the operation was 80-500ml. No postoperative complication occurred. Neither local recurrence nor metastasis was observed during a follow up of 3-48 month.【Conclusion】 The treatment with multiple endoscopic is a powerful, effective, and safe treatment modality for bilateral upper urinary tract stones.