Abstract:Objective To explore the effect of the combined application of laparoscopic radical gastrectomy (LDG) for distal gastric cancer and non-detached Roux-en-Y anastomosis.Methods The clinical data of 96 patients with gastric cancer were retrospectively analyzed who underwent LDG from January 2022 to June 2023. According to the different anastomosis methods during the operation, the patients were divided into the detached group and the non-detached group. The detached group (49 cases) underwent Roux-en-Y anastomosis, and the non-detached group (47 cases) underwent non-detached Roux-en-Y anastomosis. The intraoperative indicators, postoperative indicators, postoperative complications, nutritional index levels and quality of life of the two groups of patients were compared.Results There were no statistically significant differences between the two groups in surgical time, digestive tract reconstruction time, the number of lymph nodes cleared, hemoglobin and albumin levels at 6 months postoperatively (P 0.05). The non-detached group showed less intraoperative blood loss, shorter contrast agent gastric emptying time, exhaust time, and time to semi-liquid diet, a lower complication rate, and a higher total gastrointestinal quality of life index (GIQLI) scores compared to the detached group, with all differences being statistically significant (P 0.05).Conclusion LDG combined with non-detached Roux-en-Y anastomosis for the treatment of gastric cancer can diminish blood loss during surgery, decrease the frequency of postoperative complications, shorten the recovery time of gastrointestinal physiological functions, and have a small impact on nutrient intake, which contributes to the restoration of patients' quality of life. Therefore, it holds value for clinical practice and deserves broader application.