Abstract:Objective To explore the efficacy and safety of one-time eyeMax insight cholangiopancreatography system assisted endoscopic retrograde appendicitis therapy (ERAT) in appendicitis.Methods A retrospective analysis was conducted on the clinical data of 54 patients with uncomplicated appendicitis who were diagnosed through imaging or endoscopic examinations from April 2023 to September 2024. All patients underwent ERAT assisted by eyeMax insight cholangiopancreatography system to observe the appendiceal cavity under direct vision. Appendicitis was treated through measures such as irrigation, stone removal, dilation of stenosis and stent drainage. Observe the surgery-related indicators, the degree of postoperative pain, the occurrence of complications, the recurrence rate within one year after the operation, the manifestations under colonoscopy, the manifestations under the pancreaticobiliary imaging system and the treatment under the biliary and pancreatic duct imaging system.Results All 54 patients successfully underwent the procedure, the technical success rate was 100.0%, with a mean operative time of (60.6 ± 27.9) minutes and an average length of hospital stay of (3.6 ± 1.5) days. In 30 cases (55.6%), the opening of the appendix and the surrounding mucosa were congested and edematous, and in 2 cases (3.7%), pus and impurities could be seen flowing out. The inner walls of the appendiceal lumen of 54 cases (100.0%) were congested and edematous. Flocculent substances, pus or pus coating attached to the lumen could be seen in 51 cases (94.4%), fecalith in the lumen could be seen in 25 cases (46.3%), and the lumen was tortuous or narrowed in 15 cases (27.8%). All patients were treated with eyeMax insight cholangiopancreatography system. Simple lavage was performed in 54 cases, stone removal in a net basket in 20 cases, and stent drainage in 25 cases. The postoperative VAS score was 0 (0, 0) points, which was significantly lower than 6 (3,7) points before the operation. A comparison before and after the operation showed a statistically significant difference (Z = -6.24, P = 0.000). All patients' symptoms were temporarily relieved after the operation, and no serious adverse events such as perforation and massive hemorrhage occurred during or after the operation. Within one year of follow-up, the recurrence rate of appendicitis was 20.4% (11/54).Conclusion EyeMax insight cholangiopancreatography system assisted ERAT is a safe and effective therapy for uncomplicated appendicitis. It has the advantages of precise operation under direct vision, preservation of appendix function, rapid symptom relief, no X-ray exposure, and precise diagnosis and treatment of appendiceal lesions. It is worth applying in clinical practice.