硫酸镁钠钾与聚乙二醇电解质散在肠镜检查前肠道准备中的安全性和有效性的对比研究

Comparative study on the safety and efficacy of oral sulfate solution and polyethylene glycol in intestinal preparation before colonoscopy

摘要:

目的 比较硫酸镁钠钾口服液（OSS）与复方聚乙二醇电解质散（PEG）在结肠镜检查前肠道准备中的安全性和有效性。方法 回顾性分析2023月9月－2024年9月该院采用OSS与PEG在肠镜检查行前肠道准备的患者2 000例。根据不同肠道准备药物，将患者分为OSS组（1 000例，口服OSS）和PEG组（1 000例，口服4 L PEG）。比较两组患者肠道清洁度、清洁效果、肠腔气泡、结肠镜检查阳性率和不良反应发生率。结果 OSS组肠道准备成功率为92.5%（925/1 000），PEG组肠道准备成功率为91.7%（917/1 000），两组患者比较，差异无统计学意义（P > 0.05）；两组患者左侧结肠波士顿肠道准备量表（BBPS）评分比较，差异无统计学意义（P > 0.05），OSS组BBPS总分，以及中段和右侧结肠BBPS评分明显高于PEG组，差异均有统计学意义（P < 0.05）；OSS组气泡评估满意率为96.2%，高于PEG组的90.3%，差异有统计学意义（P < 0.05）；两组患者结肠镜检查阳性率和不良反应发生率比较，差异均无统计学意义（P > 0.05）。结论 OSS在肠道准备方面具有较好的去泡效果，清洁效果与PEG相当，且有较高的安全性。

Abstract:

Objective To compare the safety and efficacy of oral sulfate solution (OSS) and compound polyethylene glycol (PEG) for intestinal preparation before colonoscopy.Methods A retrospective analysis was conducted on 2,000 patients who underwent intestinal preparation before colonoscopy using OSS and PEG from September 2023 to September 2024. According to different intestinal preparation drugs, the patients were divided into the OSS group (1 000 cases, oral OSS) and the PEG group (1 000 cases, oral 4 L PEG). The intestinal cleanliness, cleaning effect, intestinal cavity bubbles, positive rate of colonoscopy and incidence of adverse reactions were compared between the two groups of patients.Results The evaluation results of cleaning effect showed that the success rate of intestinal preparation was 92.5% (925/1 000) in the OSS group and 91.7% (917/1 000) in the PEG group, with no statistical significance between the two groups (P > 0.05). The results of Boston bowel preparation scale (BBPS) score showed that there was no statistical significance between the two groups in left colon score (P > 0.05), but the total score, middle and right colon score in OSS group were higher than those in PEG group, with statistical significance (P < 0.05). The results of intestinal bubble evaluation showed that the satisfaction rate of bubble evaluation in OSS group (96.2%) was higher than that in PEG group (90.3%), the difference was statistically significant (P < 0.05). There was no significant difference in the positive rate of colonoscopy and the incidence of adverse events between the two groups (P > 0.05).Conclusion OSS has a good defoaming effect in intestinal preparation, and its cleaning effect is comparable to that of PEG, with high safety.