Abstract:Objective To explore the factors that may influence the operation time and complications of endoscopic unilateral thyroidectomy by a gasless unilateral axillary approach.Methods Clinical data of 203 consecutive patients who underwent endoscopic unilateral thyroidectomy by a gasless unilateral axillary approach from December 2022 to November 2023 were collected.Results Gender, BMI, TG, glandular lobe volume, number of lesions, and benign and malignant tumors affected the length of surgery; Among them, male, BMI > 19.45 kg/m2 and glandular lobe volume > 9.25 mL were independent influences on the length of surgery (P < 0.05). TG and tumor maximal diameter affected the occurrence of complications; There was no independent influence factor.Conclusion Female patients with BMI ≤ 19.45 kg/m2 and glandular lobe volume ≤ 9.25 mL (which can be measured preoperatively by 3D slicer) are relatively less difficult to perform the procedure and may be more suitable for beginners to learn.