不同时机聚乙二醇电解质散剂给药方案对肠道清洁效果的影响

The effect of different timing of polyethylene glycol electrolyte powder administration on intestinal cleansing efficacy

摘要:

目的 探讨无痛结肠镜前顿服与不同剂量间隔12 h分次口服聚乙二醇电解质散剂（PEG）对肠道清洁效果的影响，以期优化肠道准备方案，提高患者的耐受性。方法 选择2024年6月－2024年9月在该院消化内科内镜中心接受无痛结肠镜检查，并使用PEG作为肠道清洁剂的患者232例作为研究对象。将参与者分为3组：对照组（3.00 L PEG顿服组）、试验A组（0.75 L+2.25 L PEG组）和试验B组（1.50 L+1.50 L PEG组），所有患者均在服用完毕后4 ~ 6 h内进行无痛结肠镜检查。其中，试验A组和试验B组两次服用PEG的间隔时间均为12 h。通过波士顿肠道准备评分（BBPS）评估肠道清洁度，并记录结肠息肉检出率、患者不良反应、睡眠时间及耐受性。结果 3组患者BBPS评分和结肠息肉检出率比较，差异均无统计学意义（P > 0.05）。试验B组服用PEG后的不良反应最轻，其次是试验A组，对照组的不良反应最明显（P < 0.05）。不同时间口服PEG对3组患者的睡眠时间无明显影响（P > 0.05）。试验B组对PEG的耐受性良好，愿意接受此方案进行肠道准备，试验A组次之，对照组耐受性最差，3组之间比较，差异有统计学意义（P < 0.05）。结论 顿服与分次服用PEG对肠道清洁效果及结肠息肉检出率无明显影响，但间隔12 h分次PEG方案，患者不良反应轻、耐受性好，尤其是间隔12 h分2次服用1.50 L PEG方案最佳。

Abstract:

Objective To investigate the effects of a continuous-dose administration versus different dosage regimens of polyethylene glycol electrolyte solution (PEG) taken in two doses with a 12-hour interval on bowel cleansing efficacy, with the goal of optimizing bowel preparation protocols and improving patient tolerability.Methods 232 patients who underwent painless colonoscopy and used PEG as a bowel cleanser from June 2024 to September 2024 were selected as study subjects. Participants were divided into three groups: the control group (3.00 L PEG continuous dose), experimental group A (0.75 L + 2.25 L PEG), and experimental group B (1.50 L + 1.50 L PEG). All patients underwent painless colonoscopy within 4~6 h after completing PEG intake. The interval between the two doses of PEG in group A and group B was 12 h. The bowel cleansing efficacy was assessed by using the Boston bowel preparation scale (BBPS), and the rates of colon polyp detection, adverse reactions, sleep duration, and tolerability were recorded.Results There were no significant statistical differences in BBPS scores and colon polyp detection rates among the three groups (P > 0.05). Experimental group B experienced the least adverse reactions, followed by experimental group A, while the control group reported the most significant adverse reactions (P < 0.05). The timing of PEG administration did not have a significant impact on sleep duration among the three groups (P > 0.05). Patients in experimental group B showed good tolerability to PEG and were willing to accept this bowel preparation regimen, followed by group A, while the control group exhibited the poorest tolerability, with significant statistical differences among the three groups (P < 0.05).Conclusion The continuous administration and divided administration of PEG have no significant impact on the effectiveness of intestinal cleansing and the detection rate of colonic polyps. However, the divided PEG regimen with a 12 h interval results in fewer adverse reactions and better tolerance, especially the optimal regimen of taking 1.50 L PEG in two doses with a 12 h interval.