Abstract:Objective To investigate the efficacy and safety of endoscopic hematoma evacuation in treatment of non-isodense chronic subdural hematoma and subacute subdural hematoma.Method From June 2019 to June 2022, endoscopic surgery was performed on 18 cases of non-isodense chronic subdural hematoma and subacute subdural hematoma. Then analyze the indicators such as hematoma clearance rate, postoperative midline deviation reduction, surgical time, intraoperative blood loss, postoperative recurrence rate, Glasgow coma score (GCS) and modified Rankin scale (mRS) at different times.Result The average surgical time was (147.89 ± 10.29) min, the intraoperative blood loss was (130.52 ± 18.42) mL. The average preoperative hematoma volume of 18 patients was (111.91 ± 34.25) mL, on the first day after surgery, CT scan showed that all the 16 hematoma cases were cleared, and the majority of 2 hematoma cases were cleared, the average hematoma clearance rate was 88.89%. Craniocerebral CT showed an average midline displacement of (11.49 ± 3.23) mm before surgery, which returned to (6.19 ± 2.61) mm on the first day after surgery, the difference was statistically significant (P < 0.01); At 1 month after surgery, 16 patients had a median midline displacement, while 2 patients had a median midline displacement of 1.21 and 2.23 mm, the median line regression rate was 88.89% at 1 month after surgery; 6 months after surgery, all the 18 patients had a median midline displacement, and the median line regression rate was 100.00%. All the 18 patients did not experience any further bleeding after surgery, one patient developed subdural effusion after surgery, which was absorbed after taking medication. After a follow-up of six months, all the 18 patients did not recur. The GCS on admission was (14.06 ± 2.46), which improved to (15.00 ± 0.00) at discharge, with a statistically significant difference (P < 0.05); mRS on admission was (3.17 ± 1.26), and decreased to (0.56 ± 0.02) at discharge, with statistical significance (P < 0.05).Conclusion Endoscopic removal of chronic and subacute subdural hematomas with non-isodense is a safe and effective method of hematoma removal. While achieving the effect of large bone flap craniotomy, it can significantly reduce the surgical complications and postoperative recurrence, have a less invasive. It is worthy clinical application.