Abstract:Objective To explore the method of treating otosclerosis with endoscopic artificial stapes implantation assisted by CO2 laser perforation, then verify its safety and observe the therapeutic effect.Methods From January 2017 to December 2023, 21 patients (22 ears) with otosclerosis who met the inclusion criteria were selected for the study. Under endoscopy, CO2 laser was used to punch the stapes floor plate and perform artificial stapes implantation. Postoperative hearing recovery and complications such as facial paralysis, dysgeusia, vertigo, tympanic membrane perforation, and tinnitus were observed.Results The postoperative air conduction threshold was (47.49 ± 13.56) dB HL, which was a reduction of (11.72 ± 13.42) dB HL compared to the preoperative air conduction threshold of (59.20 ± 9.95) dB HL.The difference was statistically significant (P < 0.01). The postoperative bone conduction threshold was (28.45 ± 10.70) dB HL, which decreased by (0.31 ± 7.44) dB HL compared to the preoperative bone conduction threshold of (28.77 ± 8.39) dB HL. The difference was not statistically significant (P > 0.05).The postoperative air-bone gap (A-B gap) was (19.03 ± 8.76) dB HL, which was a significant decrease compared to the preoperative A-B gap of (30.44 ± 8.60) dB HL, showing an improvement of (11.40 ± 9.74) dB HL. The difference was statistically significant (P < 0.01). One case of sensorineural hearing loss occurred postoperatively, but no cases of facial paralysis, dysgeusia, or postoperative infection complications were observed.Conclusion The treatment of otosclerosis with artificial stapedial implantation assisted by CO2 laser perforation under endoscopy is safe and reliable, significantly improving patients' hearing indicators, with a low incidence of complications, and is worth promoting in clinical practice.