Abstract:Objective To explore the advantages and safety of laparoscopic operation compared with open surgery for the treatment of acute appendicitis in pregnancy.Methods The clinical data of 22 patients with early, middle and late pregnancy acute appendicitis from November 2004 to April 2023 were retrospectively analyzed. They were divided into laparoscopic operation group (n = 9) and open group (n = 13) according to the operation method. The infection indicators and fetal outcome indicators were compared between the two groups.Results Comparison of hospitalization time, intraoperative bleeding, drain placement rate, C-reactive protein, procalcitonin, antibiotic use time, incision infection rate, abdominal infection rate, fertility preservation treatment time, pathological manifestations, preterm delivery rate, delivery mode, fetal survival rate between the two groups, the differences were not statistically significant (P > 0.05); the operation time of laparoscopic group was longer than that of open group, postoperative analgesic use time, postoperative time of first feeding and postoperative anal defecation time were shorter than those of open group, postoperative leukocyte count was lower than that of open group, the differences were all statistically significant (P < 0.05), and anesthesia mode was statistically significant (P < 0.05).Conclusion Laparoscopic surgery is safe and feasible for the treatment of appendicitis in pregnancy. Compared with laparotomy, it has the advantages of small incision, beautiful incision, fast intestinal recovery, early feeding, less infection, good maternal-fetal outcome and high fetal safety.