Abstract:Objective To evaluate the effect of manual massage on complications after endoscopic foam sclerotherapy injection for the treatment of internal hemorrhoids.Methods Consecutive 113 patients with grade Ⅰ internal hemorrhoids were prospectively enrolled and completed endoscopic foam sclerotherapy. The patients were randomly divided into a massage group (n = 65) and a control group (n = 68). Massage group performed manual perianal massage, Visual analogue scale (VAS) was used to evaluate perianal pain. The postoperative bleeding, short-term and long-term efficacy were also compared.Results The median VAS of 24 h postoperation was 1.0 (0.0, 3.0) in massage group, which was significantly lower than 2.0 (1.0, 4.0) in control group, the difference was statistically significant (P = 0.014). The no bleeding rate of one week postoperation was 84.6% in massage group, which was significantly higher than 64.7% in control group, the difference was statistically significant (P = 0.009). After 12 weeks, 6 months and 12 months of follow-up, there were no significant differences in cure rate and remission rate between the two groups (P > 0.05).Conclusion Manual massage after endoscopic sclerosing agent injection is beneficial to relieve postoperative pain of grade I internal hemorrhoids and reduce bleeding.