Abstract:Objective To examine the occurrence of sore throat following painless gastroscopy and to analyze the associated risk factors.Methods A cohort of outpatient patients who underwent painless gastroscopy between October and November 2019 were selected for this study. A questionnaire was designed by the research team to gather relevant data. Starting 24 h after the procedure, telephone follow-ups were conducted every 24 h until the postoperative sore throat completely subsided. The severity of postoperative sore throat were assessed using numerical rating scale (NRS) and the duration was recorded. Patients were categorized into two groups: those with postoperative sore throat (Group Ⅰ) and those without (Group Ⅱ). Multivariate Logistic regression analysis was performed on statistically significant factors between the two groups to identify independent influencing factors of postoperative sore throat in painless gastroscopy patients.Results Out of 608 patients who participated in the study, 42 developed postoperative sore throat, resulting in an incidence rate of 6.91%. The NRS score averaged 3.00 (2.00, 4.25), with a median duration of 24.0 (10.0, 48.0) h, with the longest duration recorded at 192 h (in one case). Age and fatigue degree in the preoperative three days were independent influencing factors for postoperative sore throat: for every 1 year increase in age, the incidence of postoperative sore throat decreased by 2.60%; moderate fatigue and severe fatigue in the preoperative three days were risk factors for postoperative sore throat.Conclusion Sore throat following painless gastroscopy warrants attention. For every 1 year increase in age, the incidence of postoperative sore throat decreases by 2.60%; moderate fatigue and severe fatigue in the preoperative three days are risk factors for postoperative sore throat.