环泊酚复合芬太尼在胃镜检查中的应用剂量分析

Dose analysis of ciprofol combined with fentanyl in patients undergoing gastroscopy

摘要:

目的 分析环泊酚复合芬太尼在胃镜检查中的应用剂量。方法 选取2021年6月－2023年6月该院收治的99例胃镜检查患者作为研究对象，采用随机数表法分为3组，各33例。A组给予0.3 mg/kg环泊酚+1.5 μg/kg芬太尼麻醉，B组给予0.4 mg/kg环泊酚+1.5 μg/kg芬太尼麻醉，C组给予0.5 mg/kg环泊酚+1.5 μg/kg芬太尼麻醉。比较3组患者麻醉情况、检查情况、脑电双频指数（BIS）、平均动脉压（MAP）、心率（HR）和不良反应发生情况。结果 A组首次麻醉成功率低于B组和C组，胃镜检查时间长于B组和C组，苏醒时间和离院时间短于B组和C组，B组苏醒时间和离院时间短于C组，A组T₂、T₃、T₄和T₅时点的BIS高于B组和C组，A组T₂、T₃、T₄和T₅时点MAP和HR水平低于B组和C组，A组体动和呛咳发生率高于B组和C组，C组低血压和恶心呕吐发生率高于A组和B组，差异均统计学有意义（P < 0.05）；A组和C组各1例患者因低氧血症停止胃镜操作，B组未出现低氧血症，差异无统计学意义（P > 0.05）；A组4例、B组6例和C组10例因低血压给予血管活性药物干预，差异有统计学意义（P < 0.05）。结论 胃镜检查采用0.4 mg/kg环泊酚+1.5 μg/kg芬太尼麻醉方案，能够获取较佳的麻醉效果，缩短检查时间和离院时间，稳定患者生命体征，降低不良反应发生率。

Abstract:

Objective To analyze the application dose of ciprofol combined with fentanyl in patients undergoing gastroscopy.Method 99 gastroscopy patients from June 2021 to June 2023 were selected as the study objects, and divided into three groups with 33 cases each by random number table method. Group A was given 0.3 mg/kg ciprofol + 1.5 μg/kg fentanyl anesthesia, group B was given 0.4 mg/kg ciprofol + 1.5 μg/kg fentanyl anesthesia, group C was given 0.5 mg/kg ciprofol + 1.5 μg/kg fentanyl anesthesia. Anesthesia, examination, electroencephalogram bispectral index (BIS), mean arterial pressure (MAP), heart rate (HR) and adverse reaction were compared among all groups.Results The success rate of the first anesthesia in Group A was lower than that in Group B and Group C, the gastroscopy examination time was longer than that in Group B and Group C, and the awakening time and hospital leave time were shorter than those in Group B and Group C, the awakening time and hospitalization time of Group B were shorter than those of Group C, the BIS of Group A at time points T₂ to T₅ was higher than that of Group B and Group C, the MAP and HR levels at time points T₂ to T₅ in Group A were lower than those in Group B and Group C, the incidence of body movement and coughing in Group A was higher than that in Group B and Group C, the incidence of hypotension and nausea and vomiting in Group C was higher than that in Group A and Group B, and the differences were statistically significant (P < 0.05). One patient in Group A and one patient in Group C stopped gastroscopy due to hypoxemia, Group B did not experience hypoxemia, and the difference was not statistically significant (P > 0.05). There were 4 cases in Group A, 6 cases in Group B and 10 cases in Group C who received intervention with vasoactive drugs due to hypotension, and the difference was statistically significant (P < 0.05).Conclusion Patients undergoing gastroscopy which should use 0.4 mg/kg ciprofol + 1.5 μg/kg fentanyl anesthesia can achieve better anesthesia effect, shorten examination time and hospitalization time, stabilize vital signs, and reduce adverse reaction incidence rate.