Abstract:Objective To explore the clinical effect of underwater cold snare polypectomy (CSP) for the treatment of small colorectal polyps.Method A total of 186 patients with small colorectal polyps (5~10 mm) admitted to the hospital from July 2021 to June 2022 were selected for the study. They were randomly divided into underwater CSP group (n = 93) and traditional CSP group (n = 93). To compare the polyp surgery time, polyp complete resection rate, specimen retrieved rate, consumed clips, intraoperative and postoperative bleeding complications, and recurrence between the two groups.Results There were 156 polyps in underwater CSP group and 140 polyps in traditional CSP group. The complete resection rate in underwater CSP group was significantly higher than that in traditional CSP group (95.51% and 89.29%), the difference was statistically significant (P < 0.05); The incidence of intraoperative bleeding in underwater CSP group was significantly lower than that in traditional CSP group (13.46% and 23.57%), the difference was statistically significant (P < 0.05); The specimen retrieval rate in underwater CSP group was significantly higher than that in traditional CSP group (99.36% and 95.71%), the difference was statistically significant (P < 0.05); The surgical time of single polyp in underwater CSP group was significantly shorter than that in traditional CSP group [(86.23 ± 33.66) and (111.77 ± 40.06) s], the difference was statistically significant (P < 0.01). There were no significant differences in terms of consumed clips, postoperative bleeding incidence, and polyp recurrence rate between the two groups (P > 0.05). There were no cases of perforation in either group.Conclusion Underwater CSP is a safe and effective treatment for small colorectal polyps, with a higher complete resection rate, lower intraoperative bleeding rate, and shorter surgical time.