艾司氯胺酮复合环泊酚在老年患者结肠镜检查去阿片化麻醉中的应用
作者:
作者单位:

保定市第一中心医院 麻醉科,河北 保定 071000

作者简介:

通讯作者:

基金项目:


Application of opioid-free anesthesia with Esketamine and Ciprofol for the elderly underwent colonoscopy
Author:
Affiliation:

Department of Anaesthesiology, Baoding No.1 Central Hospital, Baoding, Hebei 071000, China

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    目的 初步探讨艾司氯胺酮复合环泊酚用于老年患者结肠镜检查去阿片化麻醉的效果。方法 选择该院行无痛结肠镜检查的患者160例,随机分为艾司氯胺酮组(E组,n = 80)和舒芬太尼组(S组,n = 80)。E组静脉注射艾司氯胺酮0.2 mg/kg,S组静脉注射舒芬太尼0.1 μg/kg。然后两组均静脉注射环泊酚0.2 mg/kg。记录诱导前平静时(T0)、诱导后改良警觉/镇静(MOAA/S)评分为0分时(T1)、结肠镜通过肝曲时(T2)和检查结束撤出结肠镜后(T3)各时点平均动脉压(MAP)、心率(HR)和经皮动脉血氧饱和度(SpO2);并记录麻醉诱导时间、完全清醒时间、麻醉成功率、环泊酚追加剂量、满意度评分和不良反应发生率。结果 与T0时点比较,两组患者T1、T2和T3时点MAP降低;E组T1时点HR降低,S组T1、T2和T3时点HR降低;S组T1和T2时点SpO2降低,差异均有统计学意义(P < 0.05)。与T1时点比较,两组T2时点MAP和HR升高,差异均有统计学意义(P < 0.05)。与E组比较,S组T1、T2和T3时点MAP降低,T1和T2时点HR和SpO2降低,差异均有统计学意义(P < 0.05)。与E组比较,S组环泊酚追加剂量、低氧血症发生率和低血压发生率增加,麻醉医师满意度降低,差异均有统计学意义(P < 0.05)。结论 艾司氯胺酮去阿片化麻醉用于老年患者结肠镜麻醉,低氧血症和低血压发生率低,安全可行。

    Abstract:

    Objective To observe the effect of opioid-free anesthesia with esketamine and ciprofol for the elderly underwent colonoscopy.Methods 160 elderly patients underwent colonoscopy were included in this study. Those patients were assigned to esketamine combined with ciprofol group (group E, n = 80) and sufentanil combined with ciprofol (group S, n = 80). Patients were intravenously injected respectively with esketamine 0.2 mg/kg in group E and sufentanil 0.1 μg/kg in group S. Then, all the patients were intravenously injected with ciprofol (0.2 mg/kg). Mean arterial pressure (MAP), heart rate (HR) and percutaneous arterial oxygen saturation (SpO2) were recorded before injection of test drug (T0), when modified observer’s assessment of alertness/sedation (MOAA/S) score was 0 points (T1), when colonoscopy through hepatic flexure (T2) and colonoscopy was removed after examination (T3). The induction time of anesthesia, time of fully awake, rate of successful anesthesia, additional dose of ciprofol, satisfaction score and incidence of adverse events were recorded.Results Compared with T0, MAP at T1, T2 and T3 in two groups was decreased, HR at T1 in group E, HR at T1, T2 and T3 in group S and SpO2 at T1 and T2 in group S were decreased, the differences were statistically significant (P < 0.05). Compared with T1, MAP and HR at T2 in two groups were increased, the differences were statistically significant (P < 0.05). Compared with group E, MAP in group S at T1, T2 and T3, HR and SpO2 at T1 and T2 in group E were decreased, the differences were statistically significant (P < 0.05). Compared with the group E, the additional dosage of ciprofol, the incidence of hypoxemia and hypotension were increased, the satisfaction of anesthesiologists was decreased in group S, the differences were statistically significant (P < 0.05).Conclusion For opioid-free anesthesia, esketamine is feasible for colonoscopy anesthesia in elderly patient, and the incidence of hypoxemia and hypotension is low.

    参考文献
    相似文献
    引证文献
引用本文

赵克非,王超.艾司氯胺酮复合环泊酚在老年患者结肠镜检查去阿片化麻醉中的应用[J].中国内镜杂志,2024,30(3):66-72

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:2023-07-24
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2024-04-03
二维码
中国内镜杂志声明
关闭