双倍剂量链霉蛋白酶服用时机对磁控胶囊胃镜检查效果的影响

Effect of the timing of double-dose pronase administration on the effect of magnetically controlled gastric capsule endoscope

摘要:

目的 探讨双倍剂量链霉蛋白酶的服用时机对磁控胶囊胃镜（MCE）检查质量的影响。方法 选取2021年2月－2022年3月于该院行MCE检查的225例患者作为研究对象，随机分为3组，A组检查前40 min口服链霉蛋白酶40 000 u；B组检查前60和40 min分次口服20 000 u；C组检查前40和20 min分次口服20 000 u。记录胃部6个区域的胃腔清洁度和黏膜可视化程度评分（1～4分）、病变检出率和胃观察时间。结果 共221例患者完成研究。黏膜可视化程度评分中，C组为（23.56±1.37）分，高于A组的（22.56±1.28）分和B组的（23.00±1.33）分，差异有统计学意义（P < 0.05）。胃腔清洁度评分中，C组为（21.44±2.35）分，高于A组的（20.11±2.04）分，差异有统计学意义（P < 0.01）。在近端胃（贲门和胃底）的清洁度评分和黏膜可视化程度评分中，C组高于A组和B组，差异有统计学意义（P < 0.05）。病变检出率中，C组胃息肉和糜烂检出率分别为17.8%和49.3%，高于A组（6.8%和29.7%）和B组（9.5%和31.1%），差异均有统计学意义（P < 0.05）。C组胃观察时间短于A组和B组，差异有统计学意义（P < 0.05）。结论 在检查前40和20 min分次口服20 000 u链霉蛋白酶，可以提高MCE的检查质量。

Abstract:

Objective To investigate the effect of the timing of pronase on the quality of magnetically controlled gastric capsule endoscope (MCE).Methods 225 patients from February 2021 to March 2022 were randomly assigned to 3 groups, 40 000 u of oral pronase 40 min before examination in Group A, 20 000 u of oral pronase for 60 and 40 min before the examination in Group B, 20 000 u of oral pronase for 40 and 20 min before examination in Group C. Gastric cavity cleanliness and gastric mucosa visualisation scores (1 to 4) were recorded for the six regions of the stomach and the sum of the scores was calculated. The detection rate of gastric lesions such as gastric polyps and the time of gastric examination were also recorded.Results 221 patients completed the study. In the mucosal visualization score, group C scored (23.56 ± 1.37) points, which was higher than that in group A's (22.56 ± 1.28) points and group B's (23.00 ± 1.33) points. The difference was statistically significant (P < 0.05). In the gastric cavity cleanliness score, group C scored (21.44 ± 2.35) points, which was higher than that in group A's (20.11 ± 2.04) points. The difference was statistically significant (P < 0.01). In the total score of cleanliness and mucosal visualization score of the proximal stomach (cardia and fundus), group C was higher than group A and group B, and the difference was statistically significant (P < 0.05). In the detection rate of lesions, the detection rates of gastric polyps and erosion in group C were 17.8% and 49.3%, respectively, which were higher than group A's (6.8% and 29.7%) and group B's (9.5% and 31.1%). The differences were statistically significant (P < 0.05). The gastric observation time in group C was shorter than that in group A and group B, and the difference was statistically significant (P < 0.05).Conclusions Oral administration of 20 000 u of pronase in divided doses 40 and 20 min before the examination can enhance the quality of magnetically controlled gastric capsule endoscope.