Abstract:Objective To present our initial experience of suturing uterine blood vessels with barbed polydioxanone cog thread by single-port-access large laparoscopic hysterectomy.Methods A respective non-randomized study with two parallel groups was performed from June 2021 to June 2022. The medical records of a total of 41 patients with enlarged uterus were divided into two groups: The single-port access large laparoscopic hysterectomy group by suturing uterine blood vessels with barbed cog thread (experimental group, n = 20), and the four-port assess laparoscopic hysterectomy group (control group, n = 21). The age, body mass index (BMI), a history of abdominal and pelvic surgery, pre- and post-operative hemoglobin (HGB), operative duration, intraoperative bleeding volume, uterine weight, postoperative pain visual analogue scale (VAS) at 24 h, the first postoperative exhaust time and postoperative length of hospital stay were compared between the two groups.Results 41 patients completed the entire procedure successfully without serious complications. Experimental group had a longer median operative time (P < 0.01). There were no significant differences in intraoperative bleeding volume, uterine weight, HGB on postoperative day 1, postoperative hospital stays, postoperative exhaust time and postoperative 24-hour pain VAS (P > 0.05).Conclusion Our study shows that suturing uterine blood vessels with barbed polydioxanone cog thread in experimental group is safe and feasible for large uterus , but the surgical time is significantly longer than the control group, as the technology becomes more proficient, this situation will be improved.