结直肠癌转录因子激活蛋白2α和2β表达与腹腔镜下根治术后复发的临床关系

Clinical relationship between TFAP-2α and TFAP-2β expression in colorectal cancer and recurrence after laparoscopic radical surgery

摘要:

目的 探讨结直肠癌转录因子激活蛋白2α（TFAP-2α）和转录因子激活蛋白2β（TFAP-2β）表达与腹腔镜下根治术后复发的临床关系。方法 选取该院收治的147例行腹腔镜根治术的结直肠癌患者作为研究对象，采用免疫组化法检测TFAP-2α和TFAP-2β表达。根据患者术后3年的复发情况，将其分为复发组和未复发组，比较癌组织与切缘正常组织、复发组与未复发组中TFAP-2α和TFAP-2β的表达，并采用Cox回归分析法探讨术后复发的影响因素。结果 结直肠癌患者癌组织与切缘正常组织相比，TFAP-2α和TFAP-2β阳性表达率较低（P < 0.05）。随访期间，结直肠癌患者术后复发率为23.13%。复发患者与未复发患者相比，癌组织TFAP-2α和TFAP-2β阳性表达率较低，以及病理分期T₃至T₄期、N₁至N₂期和血管侵犯占比较高（P < 0.05）；经Cox回归分析显示，病理分期T₃至T₄期、N₁至N₂期、血管侵犯占比较高，以及癌组织TFAP-2α、TFAP-2β阳性表达率降低，是结直肠癌患者腹腔镜下根治术后复发的危险因素（P < 0.05）。结论 结直肠癌患者癌组织TFAP-2α和TFAP-2β阳性表达率较低，两者阳性表达率降低，以及病理分期T₃至T₄期、N₁至N₂期和血管侵犯占比较高，是结直肠癌患者腹腔镜下根治术后复发的危险因素。

Abstract:

Objective To investigate the clinical relationship between transcription factor activator protein 2α (TFAP-2α) and transcription factor activator protein 2β (TFAP-2β) expression in colorectal cancer and recurrence after laparoscopic radical surgery.Methods 147 colorectal cancer patients who underwent laparoscopic radical resection were selected as the research objects. The expressions of TFAP-2α and TFAP-2β proteins were detected by immunohistochemical method. According to the recurrence of the patient 3 years after surgery, they were divided into the recurrence group and the non-recurrence group. Comparing the expression of TFAP-2α and TFAP-2β between cancer tissue and normal tissue at the cutting edge, as well as between the recurrence group and the non-recurrence group. The influencing factors of recurrence were analyzed by Cox regression analysis.Results The positive expression rates of TFAP-2α and TFAP-2β proteins in colorectal cancer tissue were lower than those in normal tissues at the cutting edge (P < 0.05). During the follow-up period, the postoperative recurrence rate of colorectal cancer patients was 23.13%. The positive expression rates of TFAP-2α and TFAP-2β proteins in recurrence patients were lower than those in non-recurrence patients (P < 0.05). The proportions of pathological stages T₃ to T₄, N₁ to N₂, vascular invasion stage in cancer tissues of recurrent patients were higher than those of non-recurrence patients (P < 0.05). Cox regression analysis showed that pathological stages T₃ to T₄, N₁ to N₂, vascular invasion and the decrease of cancer tissue TFAP-2α and TFAP-2β proteins positive expression rates were risk factors for recurrence after laparoscopic radical resection of colorectal cancer (P < 0.05).Conclusion The positive expression rates of TFAP-2α and TFAP-2β in cancer tissue of colorectal cancer patients are lower. The decrease of their positive expression rate, the high proportion of pathological stages T₃ to T₄, N₁ to N₂ and vascular invasion are risk factors for recurrence after laparoscopic radical resection of colorectal cancer.