阿芬太尼复合七氟醚对宫腔镜手术患者术中生命体征和苏醒质量的影响

Effect of Alfentanil compounded with Sevoflurane on intraoperative vital signs and quality of awakening in patients undergoing hysteroscopic surgery

摘要:

目的 探讨阿芬太尼复合七氟醚对宫腔镜手术患者术中生命体征和苏醒质量的影响。方法 选取2021年7月－2022年8月于该院行日间宫腔镜手术的患者80例，采取随机数表法分为两组。对照组采用瑞芬太尼复合七氟醚（R组，n = 40），观察组采用阿芬太尼复合七氟醚（A组，n = 40）。比较分析两组患者在不同时点的生命体征［心率（HR）、平均动脉压（MAP）和呼吸频率（RR）］变化、苏醒时间、定向力恢复时间、视觉模拟评分（VAS）和不良反应等。结果 与R组比较，A组的苏醒时间和定向力恢复时间明显缩短，不同时点的HR、MAP和RR更平稳，氧合指数（PaO₂/FiO₂）较高，动脉血二氧化碳分压（PaCO₂）较低，不同时点VAS较低，围手术期不良反应发生率更低，差异均有统计学意义（P < 0.05）。结论 阿芬太尼复合七氟醚在宫腔镜手术患者中的应用效果较好，可以有效地监测和维持患者在手术过程中的生命体征，提高患者术后的苏醒质量，减少不良反应的发生。

Abstract:

Objective To investigate the effects of Alfentanil compounded with Sevoflurane on intraoperative vital signs and quality of awakening in patients undergoing hysteroscopic surgery.Method 80 patients who underwent daytime hysteroscopic surgery in our hospital from July 2021 to August 2022 were selected, and randomly divided into two groups. The control group received Remifentanil combined with Sevoflurane (group R, n = 40), and the observation group received Alfentanil combined with Sevoflurane (group A, n = 40). Comparative analysis of changes in vital signs [heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR)], time to awakening, time to recovery of orientation, visual analogue scale (VAS), and adverse effects at different time points in two groups.Results Compared with group R, group A had shorter awakening time and orientation recovery time, smoother HR, MAP and RR at different time points, higher partial pressure of oxygen in arterial blood/fractional concentration of inspiratory oxygen，oxygenation index (PaO₂/FiO₂), lower partial pressure of carbon dioxide in arterial blood (PaCO₂), lower VAS at different time points, and fewer incidences of perioperative adverse events, the differences were statistically significant (P < 0.05).Conclusion Alfentanil compounded with Sevoflurane is more effective in patients undergoing hysteroscopic surgery. The use of this method can effectively monitor and maintain the patient's vital signs during the procedure, thus improving the quality of postoperative awakening quality and reducing possible adverse effects.