Abstract:Objective To study the clinical effect of endoscopic cold snare polypectomy (CSP) on small colorectal polyps.Methods 118 patients with small colorectal polyps (diameter ≤ 10 mm) treated in the hospital from January 2020 to January 2022 were selected as the research subjects, and they were divided into control group (n = 59) and observation group (n = 59) according to the random coin toss method. The control group was treated with endoscopic hot snare polypectomy (HSP), while the observation group was given endoscopic CSP. The polyp resection, surgical indicators, polyp resection rate, intraoperative and postoperative complications and recurrence were compared between the two groups.Results The surgical procedure time in the observation group was shorter than that in the control group, the different was statistically significant (P < 0.05). The histological complete resection rate and resection rate of polyps with a diameter of 1~5 mm were higher than those in the control group, the differences were statistically significant (P < 0.05). The bleeding rate during surgery, bleeding rate at 2 weeks after surgery and hemostasis rate under endoscope in the observation group were lower than those in the control group, the differences were statistically significant (P < 0.05).Conclusion Endoscopic CSP has shorter surgical procedure time, higher polyp resection rate and fewer intraoperative and postoperative complications in the treatment of small colorectal polyps, and it is a safe and effective treatment method.