Abstract:Objective To analyze the possible etiology, clinical and endoscopic characteristics and appropriate treatment of pneumatosis cystoides intestinalis of colon.Methods Clinical data of 33 patients diagnosed with pneumocysts of colon from May 2017 to March 2022 were analyzed and summarized.Results 33 cases of colonic balloon cyst were included, including 20 males and 13 females, and the age was (56.58 ± 11.69) years; the detection rate of the disease: 0.11%. Asymptomatic patients accounted for 30.30% (10/33), and the main clinical symptoms were as follows: There were 12 cases of abdominal pain (36.36%), 12 cases of abdominal distension (36.36%), 10 cases of diarrhea (30.30%), 5 cases of constipation (15.16%), 5 cases of hematochezia (15.16%), 1 case of weight loss (3.03%), and 2 cases of Elevated CEA (6.06%). Compared with the 21 cases of single cyst and 12 cases of multiple cyst, there was no significant difference in age, gender, protopathy, combined with other endoscopic diagnosis under colonoscopy, clinical symptoms, diameter of cyst and distribution of intestinal segments (P > 0.05). There was a statistically significant difference in the surface condition (smooth, erythema, and erosion) of the lesions between 21 cases of single cyst and 12 cases of multiple cysts (P < 0.05).Conclusion Colonic pneumocysts are relatively rare in clinic, and their clinical manifestations are not typical. Minimally invasive treatment under endoscope is an effective treatment measure, and most of the disease has a good prognosis.