布托啡诺与舒芬太尼复合丙泊酚用于无痛肠镜中的效果研究

Study on the effect of butorphanol and sufentanil combined with propofol in painless colonoscopy

摘要:

目的 探讨布托啡诺和舒芬太尼在无痛肠镜检查中的应用效果。方法 选择2021年1月－2022年1月该院收治的无痛肠镜检查患者200例，根据不同的麻醉方案分为舒芬太尼组（S组，100例）和布托啡诺组（B组，100例）。比较两组患者不同时点的生命体征参数、丙泊酚总用量、麻醉苏醒时间、麻醉诱导时间、术中术后不良反应发生率和术后清醒30 min的视觉模拟评分（VAS）。结果 两组患者在T₂和T₃时点平均动脉压（MAP）和心率（HR）均低于T₁时点，且呈现逐渐下降的趋势，B组高于S组，下降趋势相对缓慢（P < 0.05）。T₄和T₅时点，两组患者的MAP和HR恢复至麻醉前水平，组间比较，差异均无统计学意义（P > 0.05）。两组患者各时点组间和组内的经皮动脉血氧饱和度（SpO₂）比较，差异均无统计学意义（P > 0.05）。两组患者丙泊酚总用量、麻醉苏醒时间及麻醉诱导时间比较，差异均无统计学意义（P > 0.05）。B组术中心动过缓、呛咳、术后恶心和呕吐发生率低于S组，差异均有统计学意义（P < 0.05）；两组患者术中低血压、呼吸抑制、体动、术后嗜睡和头晕发生率比较，差异均无统计学意义（P > 0.05）。B组术后清醒30 min的VAS低于S组，差异有统计学意义（P < 0.05）。结论 布托啡诺复合丙泊酚在无痛肠镜检查中的应用效果较理想，麻醉过程安全平稳，可有效减少不良反应的发生。

Abstract:

Objective To explore the effect of butorphanol and sufentanil in painless colonoscopy.Methods From January 2021 to January 2022, 200 patients with painless colonoscopy were selected and divided into sufentanil group (group S, 100 cases) and butorphanol group (group B, 100 cases) according to different anesthesia schemes. The vital sign parameters, the total dosage of propofol, the time of awakening and induction of anesthesia, the incidence of adverse reactions during and after operation, and the visual analogue scale (VAS) of 30 min after operation were compared between the two groups at different time points.Results On the T₂ and T₃ time points, the mean arterial pressure (MAP) and heart rate (HR) of the patients in the two groups were lower than those in the T₁ time point, and showed a gradual decline, group B was higher than group S, and the decline trend was relatively slow (P < 0.05). There was no significant difference in MAP and HR between the two groups at T₄ and T₅ time points (P > 0.05). There was no significant difference in percutaneous arterial oxygen saturation (SpO₂) between the two groups at each time point (P > 0.05). There was no significant difference between the two groups in total dosage of propofol, anesthesia recovery time and anesthesia induction time (P > 0.05). The incidence of intraoperative bradycardia, bucking, postoperative nausea and vomiting in group B were significantly lower than those in group S (P < 0.05); There was no statistically significant difference in the incidence of intraoperative hypotension, respiratory depression, body movement, postoperative drowsiness, and dizziness between the two groups (P > 0.05). The VAS after 30 minutes of postoperative awakening in Group B was lower than that in Group S, with a statistically significant difference (P < 0.05).Conclusion The application of butorphanol combined with propofol in painless colonoscopy is ideal, the anesthesia process is safe and stable, and can effectively reduce adverse reactions.