Abstract:Objective To explore the effect of femoral nerve + sciatic+lateral femoral cutaneous nerve block in arthroscopy of knee osteoarthritis (KOA).Methods 86 patients with KOA who planned to be treated by knee arthroscopy from May 2019 to October 2021 were selected and divided into observation group and control group according to random number table method, with 43 cases in each group. The control group received continuous epidural anesthesia, while the observation group was anesthetized by femoral nerve + sciatic + lateral femoral cutaneous nerve block. The onset time and duration time of motor and sensory block were compared between the two groups, and the effects of anesthesia and heart rate (HR) and mean arterial pressure (MAR) were compared before anesthesia (T0), 5 min after anesthesia (T1), 10 min after the start of surgery (T2), 30 min after the start of surgery (T3) and at the end of operation (T4), and the incidence of total adverse reactions was also compared.Results The onset time of motor and sensory nerve block in the observation group were shorter than that in the control group (P < 0.05), and the duration time of motor and sensory nerve block in the observation group were longer than that in the control group (P < 0.05). There were significant differences in the HR and the MAP among groups, time and interaction (P < 0.05), and there were statistically significant differences in HR between T0 and T1 and T1 and T3 in the control group (P < 0.05), and there were statistically significant difference in MAP between T0 and T1, T2, T3, T4, as well as T1 and T3 (P < 0.05). The MAP at T1, T2, T3 and T4 in the observation group were higher than those in the control group (P < 0.05). In terms of adverse reactions, the incidence of observation group was lower than that of control group (P < 0.05).Conclusion Femoral nerve + sciatic + lateral femoral cutaneous nerve block can improve the anesthetic effect of patients in arthroscopy of KOA, and the blocking effect is ideal, which can maintain hemodynamic stability, and reduce the incidence of adverse reactions.